Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk
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چکیده
منابع مشابه
Sulfur Mustard Exposure and Non-Ischemic Central Retinal Vein Occlusion
A 41-year-old man was referred with a complaint of visual loss in his left eye and his best corrected visual acuity was 20/80. Slit lamp examination showed arborizing conjunctival vessels and dry eye. Fundus examination and fluorescein angiography revealed a non-ischemic central retinal vein occlusion. Cardiovascular, rheumatologic, and hematologic work up showed no abnormal findings. An ascert...
متن کاملProthrombin G20210A is a bifunctional gene polymorphism.
The G20210A polymorphism has been shown to alter the efficiency of prothrombin mRNA processing. Here we show that the G20210A mutation also alters prothrombin mRNA stability. Three-fold more prothrombin protein and mRNA were produced in NIH-3T3 cells transfected with the prothrombin cDNAs containing the 20210A variant compared to cells expressing the 20210G variant. mRNA stability assays using ...
متن کاملBranch Retinal Vein Occlusion followed by Central Retinal Vein Occlusion
A 59-year-old woman with history of noninsulin dependent diabetes mellitus and systemic hypertension presented with decreased vision in her left eye since 2 months ago. Bestcorrected visual acuity (BCVA) was 20/20 and 20/400 in the right and left eyes respectively. Relative afferent pupillary defect was negative. Anterior segment examination was unremarkable except for mild posterior subcapsula...
متن کاملIncreased plasma prothrombin concentration in cirrhotic patients with portal vein thrombosis and prothrombin G20210A mutation.
It was the aim of the present study to investigate factor II levels in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) carrying the heterozygous G20210A prothrombin (PT) mutation. Plasma concentrations of factor II, VII, X, V, protein C (PC) total protein S (tPS) antithrombin (AT) and D-dimers (DD) were measured in 13 LC patients with PVT heterozygous for PT G20210A, in 13 LC pa...
متن کاملStromal Cell-Derived Factor 1 Polymorphism in Retinal Vein Occlusion
BACKGROUND Stromal cell-derived factor 1 (SDF1) has crucial role in the regulation of angiogenesis and ocular neovascularisation (NV). The purpose of this study was to evaluate the association between SDF1-3'G(801)A polymorphism and NV complications of retinal vein occlusion (RVO). METHODS 130 patients with RVO (median age: 69.0, range 35-93 years; male/female- 58/72; 55 patients had central ...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2019
ISSN: 1414-431X,0100-879X
DOI: 10.1590/1414-431x20198217